Crystal structure of epoxomycin:20S proteasome reveals a molecular basis for selectivity of ,-epoxyketone proteasome inhibitors. of protein homeostasis [1C3]. This major route of controlled proteolysis of mass and misfolded protein in mammalian cells can be strictly controlled from the 26S … Continue reading Crystal structure of epoxomycin:20S proteasome reveals a molecular basis for selectivity of ,-epoxyketone proteasome inhibitors